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Infants may be born with a predisposition toward proallergic and proinflammatory T h2 immune responses, characterized by growth and activation of eosinophils and IgE production.

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In African Americans also, asthma-related death occurred at a higher rate in subjects treated with salmeterol than those treated with placebo (0.

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Immediate Hypersensitivity Reactions: Immediate hypersensitivity reactions may occur after administration of SEREVENT Inhalation Aerosol, as demonstrated by rare cases of urticaria, angioedema, rash, and bronchospasm.

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Caucasian, 18% African American, 8% Hispanic) to assess the safety of salmeterol (SEREVENT Inhalation Aerosol, 42 mcg twice daily over 28 weeks) compared to placebo when added to usual asthma therapy.

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Long-acting β-agonists produce bronchodilation and improve asthma symptoms, effects that are maintained with regular use over time ().

One National Institute of Health (NIH) funded trial showed that daily azithromycin (plus usual treatment) reduced the frequency of COPD exacerbations and improved quality of life.

The second process that contributes indirectly to sleepiness is the circadian rhythm.

Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease.

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